5-Hydroxytryptamine Stimulates Net Ca2+Flux in the Ventricular Muscle of a Mollusc (Busycon canaliculatum) During Cardioexcitation

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5-Hydroxytryptamine stimulates net Ca2+ flux in the ventricular muscle of a mollusc (Busycon canaliculatum) during cardioexcitation.

Noninvasive, self-referencing calcium (Ca2+) electrodes were used to study the mechanisms by which 5-hydroxytryptamine (5-HT) affects net Ca2+ flux across the sarcolemma of myocytes from ventricular trabeculae (from a marine gastropod, Busycon canaliculatum). Treatment of isolated trabeculae with 5-HT causes a net Ca2+ efflux, which is 30% blocked by verapamil. These findings suggest that the e...

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ژورنال

عنوان ژورنال: The Biological Bulletin

سال: 2001

ISSN: 0006-3185,1939-8697

DOI: 10.2307/1543515